U.S. Route 65 Business in Conway begins at its southern junction with U.S. Route 65 on the south side of town. From here, it travels north along Harkrider Street, initially passing through commercial areas before entering the historic downtown district of Conway. Along this segment, travelers encounter notable landmarks such as Conway Station and the campus of Hendrix College, nestled just off the main route.
Continuing north, the route intersects with U.S. Highway 64 near the northern edge of downtown. For a short stretch, US-65B runs concurrently with US-64 before turning northwest onto Skyline Drive. This area marks a transition from the older city center to more modern developments, with retail centers and residential neighborhoods lining the roadway.
The business loop ends at the northern junction with U.S. Route 65, just past the interchange with Interstate 40. This business route serves as a vital connector for local traffic between Conway’s commercial core and the surrounding highway network, offering a more scenic and historic alternative to the mainline bypass.