Interstate 75 is a major north–south artery stretching from the Canadian border at Sault Ste. Marie, Michigan, all the way to Miami, Florida. Spanning over 1,780 miles, I-75 traverses six states—Michigan, Ohio, Kentucky, Tennessee, Georgia, and Florida—serving as a vital corridor for commerce, tourism, and long-haul travel across the eastern United States. It closely parallels U.S. Route 25 in many areas and serves as a primary route for travelers heading to or from the Midwest and the Southeast.

In Michigan, I-75 begins at the international border, crosses the iconic Mackinac Bridge, and passes through cities like Detroit and Flint. It continues southward into Ohio, where it serves key metropolitan areas such as Toledo, Dayton, and Cincinnati. As it crosses into Kentucky, I-75 runs through Lexington before joining with I-64 in a shared stretch around downtown. The highway then weaves through the Appalachian ridges of Tennessee, with notable stops in Knoxville and Chattanooga.

Entering Georgia, I-75 forms a backbone of the state’s highway network, running straight through Atlanta. South of Macon, it provides access to smaller communities and serves as a direct line into Florida. In the Sunshine State, I-75 becomes known as the “Alligator Alley” between Naples and Fort Lauderdale, crossing the Everglades en route to its southern terminus in the Miami area. The route is heavily trafficked and well-maintained, with numerous service plazas and rest areas along the way, making it a preferred option for both truckers and vacationers.